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Week 5: The Genetic Welfare Frontier
Week 5: The Genetic Welfare Frontier
🧬

Week 5: The Genetic Welfare Frontier

Many traits are significantly influenced by genetic factors. Genetic modification is nothing new – humans have been selectively breeding animals and plants for thousands of years. However, recent developments like gene editing (e.g. CRISPR) and gene drives – as well as the potential of AI to accelerate further research – raise pressing questions about genetic interventions and their welfare impact. As the technology advances, the question is rapidly evolving from whether we can to whether we should. Sooner than we think, we may be asking ourselves whether it’s permissible not to use these powerful tools to help animals. To this end, it is essential to start by understanding the risks, and how to weigh genetic interventions against other approaches.

🧩 Central questions

  1. Advances in genetic modification: How do the different major techniques of genetic modification work, and what are their advantages and disadvantages?
  2. Genetic vs. non-genetic approaches to improve animal welfare: Which considerations might favour genetic interventions to improve welfare over non-genetic strategies (e.g. improving factory farming conditions; food system transformation)?
  3. The ethical gradient: What key considerations govern the acceptability of genetic editing across farmed animals, wild animals, and humans?

🧭 Learning objectives

  1. Understand: Explain in basic terms how both genetic and environmental factors contribute to trait development in sexually reproducing organisms, and differentiate major methods of genetic modification, including selective breeding, somatic vs. germline gene editing, and gene drives.
  2. Assess: Critically interrogate personal intuitions and apprehensions about genetic interventions to improve welfare. Evaluate core ethical arguments for and against genetic interventions across different animal populations (e.g. farmed, wild).
  3. Reason: Develop a principled stance on the most promising and hazardous applications of gene editing in animals. Compare and contrast genetic vs. non-genetic strategies to improve animal welfare.
  4. Next steps: Identify key organizations, contacts, and areas for further investigation into genetic welfare.
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Use the table of contents on the right to quickly navigate this page.

Resources

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A note on responsible engagement

Genetic welfare is a sensitive and high-stakes topic. This session is designed to help us explore these complex issues with clarity and charity. To this end, we ask you to approach these resources and discussions with a balanced and objective mindset:

  • Read and reflect: Treat your “gut reaction” as the start of an analysis – not the end.
  • Steelman, don’t strawman: Respond to the strongest possible version of an argument you disagree with, not a caricature. Be wary of hyberbole and sensationalism.
  • Acknowledge uncertainty: Recognize that it can hard to predict the impact (whether positive or negative) of many interventions (whether genetic or non-genetic). Strive for intellectual humility.
  • Benchmark alternatives: Compare the risks, costs, and benefits of specific genetic methods against each other and also against non-genetic welfare solutions.
  • Shared stewardship: Outside our structured fellowship environment, the risk of misunderstanding is high. Exercise discretion about where and how you discuss these ideas. Frame the conversation with nuance and humility; and be aware of potential misconceptions.
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Required readings

Please review all of these resources prior to your session.

Several readings this week are excerpts.

  • While you are welcome to explore further, you are only required to read the sections indicated with §.
  • We have extracted these sections for you, which you will find by clicking ▸ (View excerpt) below each reading.
  • Access the original link if you prefer to annotate your own copy.
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Estimated time: 1h30m

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Feel free to spend more time focusing on the readings that interest you more.

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Playback audio and video resources at faster speeds (e.g. 1.25×) to save time.

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Key concepts

This week’s readings explore the core motivations, methods, and welfare impact of genetic modification in animals. These first sections introduce key concepts for contextualizing your readings.

CRISPR: Faster, cheaper, and more precise gene editing

Much like with precision livestock farming, genetic modification involves a suite of different technologies and methods.

CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) is a revolutionary technology that allows scientists to precisely add, remove, or alter specific DNA sequences. Think of it like a word processor for the genome, enabling you to copy, cut, and paste words (genes) in a document (DNA).

What makes CRISPR such a revolutionary breakthrough is its accuracy, speed, and low cost compared to previous methods, like selective breeding.

Somatic vs. germline: Editing today or for generations?

Researchers now distinguish between two main forms of gene editing:

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Somatic editing alters DNA in non-reproductive cells, affecting only the treated individual.

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Germline editing, by contrast, modifies reproductive cells or embryos, making changes heritable.

Gene drives: Near-100% transmission to offspring

A related concept, the gene drive, uses CRISPR to “cheat” the rules of inheritance, making it much more likely that specific traits are passed on to offspring. Gene drives can be used to spread traits rapidly through populations with short reproductive cycles (like insects). This technology offers promise for controlling diseases (like malaria) but raises serious ecological and ethical concerns.

To learn more about gene editing techniques, see 🧬Week 5: The Genetic Welfare Frontier - Recent breakthroughs in gene editing in the Further readings appendix.

Genetic modification in animals

Potential animal applications span several broad categories, including but not limited to:

  • Enhanced disease resistance (e.g. against PRRS, avian flu)
  • Alternatives to painful surgical intervention (e.g. dehorning cattle, mitigating boar taint)
  • Tolerance of extreme weather conditions (e.g. heat/cold resistance)
  • Parasite elimination (see Screwworm Free Future)
Size of AquAdvantage salmon vs. non-modified salmon at 18 months of age.
Size of AquAdvantage salmon vs. non-modified salmon at 18 months of age.
  • Improved production yield (e.g. faster growth)
  • Dietary enhancements (e.g. nutritional enrichment, allergen reduction)
  • Xenotransplantation (growing human-compatible organs)
  • Environmental sustainability (e.g. decreased land/water usage, reduced emissions)
  • Directly reducing the capacity to feel pain or suffer

Genetic modification and suffering

Whether for humans or animals, genetic interventions may have different effects on welfare:

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Welfare-negative: On the whole, increases suffering.

Factory farmed chickens of today have been selectively bred to grow so rapidly that they suffer numerous
Factory farmed chickens of today have been selectively bred to grow so rapidly that they suffer numerous health complications – their legs often collapsing under their own weight. Image from Zuidhof et al (2014).
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Welfare-positive: On the whole, decreases suffering.

Commercial chicken breeds are prone to
Commercial chicken breeds are prone to vicious fighting in open spaces, a problem producers typically address by confining them in cages. Selectively breeding for lower aggression, however, creates hens better suited for group living, allowing them to be kept in more open environments. Graph from Muir (1996).
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Welfare-neutral

  • Neither increases nor decreases overall suffering, or
  • Increases in suffering are offset by other welfare improvements.

Much like with precision livestock farming and interspecies communication, the ultimate welfare impact of genetic modification will depend on many factors such as advocate involvement and leadership, market incentives, and regulatory oversight. And just like with PLF, how we define and measure welfare is also crucial – as this makes a difference to whether any given intervention is plausibly welfare-positive or welfare-negative.

Direct vs. indirect effects on welfare

Both genetic and non-genetic interventions can affect animal welfare, either directly or indirectly depending on whether they target proximal causes of suffering (e.g. slaughter methods, biological makeup) or more distal contributing factors (e.g. dietary preferences, availability of alternatives to animal products). The table below collects examples of both direct and indirect welfare-positive interventions:

Indirect welfare improvements
Direct welfare improvements
Genetic interventions
• Alternatives to painful surgical intervention (e.g. hornless cows, mitigating boar taint) • Blind chickens • In-ovo sexing of chicks • Enhanced disease resistance • Improved weather tolerance • Parasite elimination
• Reducing the capacity to feel pain/suffer
Non-genetic interventions
• Development of alt proteins and cultivated meat • Dietary change campaigning and media
• Decreased stocking density and environmental enrichment • More humane slaughter methods • Developing better diagnostics and evaluations of welfare-relevant states (e.g. stress) • Enforcing welfare standards and monitoring in factory farms (e.g. through PLF)

As you review the resources, keep these distinctions in mind and consider:

  • Which circumstances, if any, favour genetic interventions for animal welfare over non-genetic approaches?
  • There are different methods of genetic modification. What are the comparative advantages and disadvantages (e.g. costs, risks) of these techniques?
  • How might different approaches be combined?
Spectrum of welfare-relevant animal interventions: genetic/non-genetic, welfare-positive/negative, and direct/indirect.
Spectrum of welfare-relevant animal interventions: genetic/non-genetic, welfare-positive/negative, and direct/indirect.
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Genetic interventions for farmed animal welfare: the near-term

Horns in cattle can cause serious injuries to herd mates and handlers. Today, this is usually prevented through painful dehorning procedures. By introducing the naturally hornless (
Horns in cattle can cause serious injuries to herd mates and handlers. Today, this is usually prevented through painful dehorning procedures. By introducing the naturally hornless (polled) gene variant from Angus cattle into Holstein dairy cows, researchers created calves that are born hornless – eliminating the need for dehorning.

Gene Editing Could Upend the Future of Factory Farming – For Better or Worse (archived here if you encounter a paywall)

Kenny Torrella (2022) | 20 min read

For farmed animals, gene editing could alleviate suffering (hornless cows, disease resistance) or greatly exacerbate it (faster growth). This essay probes the tension between industry and advocacy, as well as the shifting regulatory landscape. There is a crucial window to determine if gene editing becomes a tool for welfare or for intensifying factory farming.

Knocking Out Pain in Livestock: Can Technology Succeed Where Morality has Stalled? (available open access here)

Adam Shriver (2009) | 2 min read (§ A potential argument only)

This excerpt outlines a clear argument for genetic welfare enhancements in farmed animals. If you have doubts or worries about genetic interventions, try to pinpoint which of the premises you take issue with – or perhaps identify if any key considerations have been left out.
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(View excerpt)

The following text is excerpted from the reading.

§ A Potential Argument I am now in a position to formulate an argument for the genetic engineering of animals reared in intensive factory farming environments:

  1. We should prevent unnecessary suffering when possible.
  2. Intensive factory farming is responsible for a considerable amount of unnecessary suffering.
  3. Replacing the current animals used in factory farming with genetically engineered animals who lack the affective dimension of pain would decrease the amount of suffering caused by factory farms.
  4. Not enough people are willing to become vegetarian to completely eliminate the suffering caused by intensive factory farming.
  5. People would be willing to eat genetically engineered food if it meant they were no longer responsible for suffering and if it did not impose too much of a burden on their lives.
  6. Animals can be genetically engineered and used in food production in a way that does not impose much of a burden on people’s lives.
  7. (7) Given (2), (3), (4), (5), and (6), replacing current livestock with genetically engineered animals who lack the affective dimension of pain would prevent unnecessary suffering.

Conclusion: From (1), and (7), we ought to replace current livestock with genetically engineered animals who lack the affective dimension of pain.

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Playing God?

A common concern about genetically modified organisms is that they violate what is natural. Yet industrial animal agriculture today is already far from natural (see previous example of selectively bred chickens). At the same time, what may seem to be radical forms of genetic interventions – like pain insensitivity – can be found in nature as well:

Three types of pain insensitivity have been documented across different species of mole rats: resistance to capsaicin, acid, and AITC (graphic from
Three types of pain insensitivity have been documented across different species of mole rats: resistance to capsaicin, acid, and AITC (graphic from Smith et al 2020).

Prioritizing the protection of welfare in gene-edited livestock

Adam Shriver (2020) | 2 min read (§ Introduction only)

This passage introduces Rollin’s principle for the conservation of welfare: “any animals that are genetically engineered for human use should be no worse off, in terms of suffering, after the new traits are introduced into the genome than the parent stock was prior to the insertion of the new genetic material”.
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(View excerpt)

The following text is excerpted from the reading.

§ Introduction

In 1995, the philosopher Bernard Rollin proposed what he called the principle for the conservation of welfare. This principle stated that, “any animals that are genetically engineered for human use should be no worse off, in terms of suffering, after the new traits are introduced into the genome than the parent stock was prior to the insertion of the new genetic material” (Rollin, 1995, p. 169). In what follows, I will argue that the global community ought to adopt a modified version of this principle in regard to all genetic modification of animals performed for nonresearch purposes. Moreover, I suggest that the principle should be enshrined in the law or regulations, and that assuming that the principle will be followed via “self-regulation” would be both morally wrong and likely to permanently damage trust in food producers.

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Potential applications of genetic modification extend beyond farmed animals. See 🧬Week 5: The Genetic Welfare Frontier - Further readings (optional) for discussion of applications in lab animals.

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Genetic vs. non-genetic approaches to improving animal welfare

Are organisms’ traits the product of their genes (“nature”) or their environment (“nurture”)? Biologists today accept that most traits are jointly determined by both.

This dual influence is crucial in the case of farmed animals, whose suffering is by and large caused by the processes involved in industrial agriculture. In considering putative genetic solutions to animal welfare problems, we must weigh the costs and benefits of adapting animals to flawed systems – rather than improving the conditions of factory farming or developing alt proteins.

Genetically Engineered Animals: From Lab to Factory Farm

Friends of the Earth (2019) | 5 min read (pages 12-14: § Are genetically engineered animals necessary in agriculture? only)

This passage argues that many proposed genetic “solutions” (like disease resistance or hornless cattle) merely treat the symptoms of intensive confinement rather than addressing the root cause. It contends that these technological “fixes” are often unnecessary, as similar welfare goals could be achieved through conventional (selective) breeding, less-intensive farming systems, and other non-genetic alternatives – without the risks (or significant costs) of genetic engineering.

Genetically Modifying Livestock for Improved Welfare: A Path Forward (available open access here)

Adam Shriver & Emilie McConnachie (2018) | 3 min read (§ The Central Problem: Comparative Disadvantages to Other Approaches only)

Some advocates worry that even well-intentioned genetic interventions may even be counterproductive to farmed animal welfare. This excerpt compares genetic interventions aimed at improving farmed animal welfare against promising non-genetic approaches – not least, alt proteins and cultivated meat.
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(View excerpt)

The following text is excerpted from the reading.

§ The Central Problem: Comparative Disadvantages to Other Approaches Though we have argued that using gene editing to improve welfare is preferable to the current status quo, this technique is nevertheless at a serious disadvantage to other possible alternatives, particularly when we consider the ethical challenges raised by a growing population and the effects of modern agriculture on the environment.

Plant-based alternatives to meat, dairy, and eggs have been impressively successful in the marketplace in recent years. In particular, plant-based dairy products have made serious headway in the total purchasing of milk; over a 5-year period between 2011 and 2015, the total milk market shrunk by $1 billion in the United States while sales of almond milk increased by 250% (Neilsen 2016). A massive societal shift towards a primarily plant-based diet would require less land usage, result in dramatically less greenhouse gas emissions, eliminate other environmental problems associated with intensive confinement operations, be more healthy than the typical American diet (and comparably healthy to diets that use small amounts of animal products), and eliminate the potential suffering of billions of animals (McMicheal et al. 2007). Considering that current realistic uses of genetic engineering on animals would address these problems only, at best, in a piecemeal fashion, and seemingly would not overcome the land and resource usage issues, they seem to be at a clear disadvantage when compared to shifting to a plant-based diet.

Another alternative that has recently been gaining momentum is the creation of lab-grown meat, referred to as ‘‘clean meat’’ by its advocates. Though many technical hurdles remain, including the ability to scaffold the grown tissue in a manner that mimics the texture of traditional meat, this technique, if successful, could all but eliminate the use of animals, dramatically reduce the usage of land and resources, and decrease much of the pollution associated with animal agriculture (Datar and Betti 2010). Unlike plant-based approaches, it is currently unclear if lab-grown meat will be successful in overcoming technical challenges, and it might also trigger similar intuitive negative reactions to genetic modification. On the other hand, the last several years have seen a rapid succession of advancements and growing investor interest in the field.

As noted above, though deontological animal rights theorists might concede that welfare enhancement is preferable to the status quo, few animal rights advocates would ever accept gene editing for welfare as an adequate end-point for social change related to animal agriculture. Raising animals for food would still be impermissible on such views. In contrast to this, a massive societal shift towards plant-based foods or in vitro meat products could presumably lead to tolerable conditions for deontological accounts of our duties to animals. This is a further advantage of these alternatives.

When compared with a shift towards plant-based diets or to in vitro meat, genetic engineering could be seen as the least attractive choice. Nevertheless, there are reasons to believe that this approach should still be pursued and, moreover, that it is possible that gene editing could be the approach that actually ends up having the most influence on the future of food despite the ethical advantages of these other options.

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Uncertainty and risks

(There are no external readings for this section, but please review the list below.)

Each type of genetic intervention has a unique risk profile. The following examples warrant special consideration:

  • Large numbers of animals and invasive procedures needed for research.
  • Entrenching and scaling factory farming: Marketed “higher welfare” meat could disincentivize deeper systemic change and directly compete with the market for alternative proteins or cultivated meat.
  • Much like invasive species, escaped or released genetically modified organisms may disrupt ecological systems in unpredictable and catastrophic ways.
  • Health effects for consumers of genetically modified food products
  • Concerns regarding patenting/intellectual property
  • Genetic defects, like brachycephalis obstructive airway syndrome (BOAS) in certain selectively bred dog breeds or off-target effects caused by gene editing. Such defects may not cause issues in some individuals (asymptomatic carriers), while in others, they may take time to become apparent. Close and extensive monitoring is therefore essential.
“I definitely am extremely worried about the idea that the initial genetic modifications that are approved are ones that are either welfare neutral or welfare positive, but they’re going to open up the floodgates for a lot of gene interventions that have very negative impacts on animal welfare.”

– Adam Shriver (2022)

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Compassionate horizons?

The following resources explore the vast future potential of genetic modification, with implications extending to wild animals and beyond.

The ideas explored herein are ambitious and speculative. We recommend approaching this material with both curiosity and prudence.

Compassionate Genomics for the 21st Century: Genomic Welfare with Ethical Care for Moral Predispositions

Ruth Seleo (2025) | 3 min read; 6 min audio available (§2 The Problem only)

The prevailing question posed by genetic modification today is: Do we have the right to do this? Tomorrow, the question may be: What right have we to withhold this?

In this EA Forum post, Ruth Seleo of the Compassionate Future Initiative argues that we may have a responsibility to use technology to reduce suffering, while also noting the influence of environmental factors on suffering.

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(View excerpt)

The following text is excerpted from the reading.

§ 2. The Problem

Despite unprecedented advances in technology, public health and welfare, we remain shaped by — and thus fundamentally constrained by — biological mechanisms based on evolutionary processes.

Biological systems are naturally mostly inegalitarian. To maintain population adaptability, organisms undergo high mutation rates, high infant mortality and many adversities throughout their lives. Frequent hardships include diseases, exploitation, scarcity and competition for resources, and age-related decay, while ensuring high reproductive output as the basis for selection pressure to form evolutionary success.

Uncontrolled evolutionary processes—particularly natural selection— do not foster widespread wellbeing, but produce vast and recurring forms of suffering.

Although humanity has increasingly protected itself from the harsh forces of natural selection through technological, economic, medical, and welfare advances, the underlying biological processes of mutation accumulation and genetic diversification persist. In most cases, these processes harm rather than benefit the affected individuals and their descendants— and will continue to do so unless actively addressed, even if artificial general intelligence (AGI) reshapes civilisation.

If evolutionary mechanisms are accepted as unchangeable, we may come to endorse Social Darwinism, discouraging compassionate welfare and health interventions. Such efforts would be seen as counterproductive to natural selection, which is assumed to be necessary for the resilience and adaptability of a species.

But rather than powerlessly enduring or ideologically defending natural suffering, we can take agency and responsibility. Through ethical applications of heritable gene editing, we could instead someday tackle many influential root causes of suffering and repair disadvantageous mutations - accumulated over centuries in wealthy, welfare-oriented societies due to the successive, purposeful removal of many suffering inducing natural selection pressures.

By implementing Genomic Welfare programs and promoting solid genetic foundations of moral behaviour, humans could foster a world where well-being is genetically supported and sustained. The prevalence of physical and psychological suffering in all sentient beings could be addressed, while maintaining adaptability and resilience of species in the face of changing environments and existential threats.

Notably, suffering has both internal (genetic) and external (environmental and social) causes. External causes of suffering—such as poverty, violence, trauma and social inequality—place immense strain on human psychological and physiological resilience.

Most external causes of suffering can be mitigated through:

  • Cultural reform that promotes moral circle expansion and prosocial values, while reducing norm-based incentives for aggression, hierarchy, and dominance.
  • Education systems that cultivate analytical, strategic and critical thinking, as well as self-reflection, mutual understanding, and cooperative behaviour.
  • Social policy that reduces economic precarity, marginalisation, and inequality.
  • Accessible, equitable healthcare that promotes public health and wellbeing in holistic and sustainable ways.
  • Built environments that are safe and support wellbeing by promoting healthy activities and strengthen community connection.

Addressing causes of suffering at its roots requires a dual approach. A sustainable long-term framework for safeguarding future wellbeing and systematically reducing preventable suffering should integrate ethically governed genomic care with comprehensive socio-environmental interventions.

Without managing genetic contributors to suffering, compensatory systems remain unsustainable in the long term.

Blueprint for a Pan-Species Welfare State (below)

David Pearce (2025) | 18 min lecture (0:42-18:44 only)

Philosopher David Pearce advocates for suffering abolition: the use of biotechnology to fully eliminate involuntary pain and suffering in all sentient beings. In this talk, Pearce explores ambitious applications of genetic modification to reduce suffering. These include regulating population sizes and herbivorizing predators to reduce wild animal suffering, as well as “hedonic uplift”: raising our affective baselines so that our “lowest lows” are on par with our “highest highs”.

Pearce’s manifesto, the Hedonistic Imperative, expands on his vision of the future. For more on this, including counter-arguments, see 🧬Week 5: The Genetic Welfare Frontier - Suffering abolition and the hedonistic imperative within the further readings.

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Further readings (optional)

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Key organizations

Screwworm Free Future

This initiative supports the use of CRISPR-based gene drives to eliminate an economically devastating parasite that also causes severe suffering to affected livestock.

The Far Out Initiative

The Far Out Initiative was a public benefit corporation conducting research into the biological foundations of pain.

To read more about the Far Out Initiative’s work, see Alexander (2024).

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Recent breakthroughs in gene editing

These resources introduce three powerful new techniques in genetic modification:

  1. CRISPR-Cas9: Enables scientists to add, remove, or alter specific DNA sequences (i.e. genes) with unprecedented precision, speed, & cost-effectiveness.
  2. Germline editing: Creating genetic changes that can be passed on to offspring
  3. Gene drives: Forcing trait inheritance, with potential to spread traits across entire populations.

Genetic Engineering Will Change Everything Forever – CRISPR (above)

Kurzgesagt (2016)

This explainer animation provides an accessible intro to CRISPR technology & its implications.

Should We Edit the Human Germline?

Jon Heggie (2018) | 5 min read

Changes caused by somatic gene editing are not passed on to offspring, while changes caused by germline gene editing are heritable. This short National Geographic article introduces the crucial distinction between somatic and germline gene editing, surveying reasons for and against germline gene editing.

Gene Editing Can Now Change an Entire Species – Forever (below)

Jennifer Kahn (2016) | 12 min talk

Gene drives are a powerful new tool which can nearly guarantee traits being passed on, enabling traits to be spread rapidly throughout an entire population.
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More on uncertainty and risks

The Ethics of Genome Editing in Non-human Animals: A Systematic Review of Reasons Reported in the Academic Literature

Nienke de Graeff et al (2019) | See especially §3 Results – (i) - (iii))

This comprehensive review compiles motivations and concerns regarding genetic editing in animals.

Is CRISPR an Ethical Game Changer? (closed access)

Marcus Schultz-Bergin (2018)

A deep dive into the myriad ethical complexities presented by CRISPR gene editing of animals.

Although dated, the following resources cover key considerations in discussions about genetic engineering of animals – many of which are still salient in the post-CRISPR age.

Genetic Engineering of Animals: Ethical Issues, Including Welfare Concerns

Elisabeth Ormandy, Julie Dale, & Gilly Griffin (2011)

Covers major genetic engineering techniques and risks.

Animal Welfare for Sale: Genetic Engineering, Animal Welfare, Ethics, and Regulation

Nina Mak (2008)

Report by a researcher at the American Anti-Vivisection Society.
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Disenhancement as welfare enhancement

Disenhancement encompasses interventions which deliberately reduce animal capacities in order to mitigate suffering – such as creating congenitally blind chickens that are less likely to be stressed by from overcrowding. A more radical form of disenhancement might involve creating “animal microencephalic lumps”: hypothetical non-sentient animals with underdeveloped brains and hence diminished or entirely absent capacity to feel pain.

Among other things, critics of disenhancement worry that efforts may to reduce animals’ capacity to suffer may end up only preventing them from expressing suffering (through their behaviour) – while they continue to feel it.

The Opposite of Human Enhancement: Nanotechnology and the Blind Chicken Problem (non-paywalled access here)

Paul Banks Thompson (2008)

This paper introduces the concept of disenhancement and explores its ethical implications.

In Defense of Neural Disenhancement to Promote Animal Welfare (closed access)

Bob Fischer (2020)

In this article, Bob Fischer of Rethink Priorities argues that neural disenhancement of animals may be permissible insofar as it implies less total suffering.

No Pain, No Gain? In Defence of Genetically Disenhancing (Most) Research Animals

Katrien Devolder & Matthias Eggel (2019)

This article argues that gene editing should be applied to reduce lab animals’ capacity for suffering.

Genetic Disenhancement and Xenotransplantation: Diminishing Pigs’ Capacity to Experience Suffering through Genetic Engineering

Daniel Rodger et al (2024)

This article defends genetic disenhancement in the case of pigs raised for organ donation to humans – so long as no viable non-animal alternatives are available.

Beyond Welfare: Animal Integrity, Animal Dignity, and Genetic Engineering (closed access) Sara Elizabeth Gavrell Ortiz (2004)

This article argues that even if disenhancement leads to suffering reduction and welfare improvements, it still violates animals’ integrity and dignity.

The 3Rs Principles and Genetic Pain Disenhancement (closed access)

Samuel Camenzinda and Matthias Eggel (2022)

W. M. S. Russell and R. L. Burch’s 3Rs framework is a seminal foundation for animals research ethics: Replace (prefer non-animal methods), Reduce (minimise animal use), and Refine (employ methods which minimise suffering and improve welfare for animals used).

This article finds that the 3Rs framework fails to account for various other harms caused by disenhancement.

For Their Own Good?: The Unseen Harms of Disenhancing Farmed Animals (available open access here)

Susana Monsó & Sara Hintze (2023)

This article also provides a critical perspective on disenhancement, instead calling for non-genetic welfare enhancements.
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Gene editing from animals to humans

The following readings bridge research into gene editing in animals with gene editing in humans.

If the relevant state being produced in the animal is analogous to the same state in humans, why are we morally entitled to produce that state in animals when we would not be so entitled to produce it in humans? And if the animal state is not analogous to the human state, then why create it in the animal?

– Bernard Rollin (2014)

Animal Disenhancement in Moral Context (closed access)

Korinn N. Murphy & William P. Kabasenche (2018)

This article likens animal disenhancement to lobotomisation in humans. While lobotomies were previously hailed for their benefits with respect to suffering reduction, they are now regarded as a medically unethical practice.

The Shared Genetics of Pain

Animal Pain Research Institute (2024) | 8 min (reading + video)

The science of pain insensitivity conditions in humans (e.g. pain asymbolia) may inform genetic interventions to reduce suffering in animals.

Genome Editing Animals and the Promise of Control in a (Post-) Anthropocentric World (closed access)

Rosine Kelz (2020)

This paper suggests that while genetic engineering technology can be seen as the ultimate expression of human control over nature, it also fundamentally challenges our anthropocentric biases by revealing the deep biological continuities between humans and other animals.
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Suffering abolition and the hedonistic imperative

Profile: The Far Out Initiative

Scott Alexander (2024)

This blog post weaves together congenital insensitivity to pain with David Pearce’s hedonistic imperative and the frontiers of pain genetics.

Dismantling the Myth that We Can't Do Anything to Help Wild Animals

Cameron Meyer Shorb, Luisa Rodriguez, Keiran Harris, & Katy Moore (2024) | see especially § Eliminating the biological basis for suffering (2:33:21-2:44:10)

In this interview segment, Cameron Meyer Shorb, Executive Director of Wild Animal Initiative, discusses ambitious interventions to eradicate suffering in wild animals.

Transhumanism and Bioethics

David Pearce (2025) | 21 min video

In this interview, David Pearce envisions a future where biotechnology is used to overcome suffering.

The Abolitionist Project (chapter 13 from Suffering Focused Ethics)

Magnus Vinding (2020) | pages 239-246

This book chapter provides a critical introduction to the suffering abolition project.

Priorities for Reducing Suffering: Reasons Not to Prioritize the Abolitionist Project

Magnus Vinding (2021)

In this blog post, Magnus Vinding expands on his analysis of the abolitionist project, cataloguing key motivations – and concerns.

Why I Don't Focus on the Hedonistic Imperative

Brian Tomasik (2017)

In this short essay, suffering-focused thinker Brian Tomasik offers critiques of Pearce’s hedonistic imperative.

Pre-session exercises

Please spend 20-30 minutes completing these two exercises.

  • You can write your responses in bullet point format if that’s easier.
  • Submit your responses in the weekly Slack thread created by your facilitator in your channel at least 24 hours before your regularly scheduled meeting.
  • Leave at least one comment on somebody else’s response.

Case studies in animal genetic editing

[150 words] Research and find an example of an animal genetic intervention (e.g., a news article, a research publication, a website, blog or forum post, etc.). Be prepared to present your example in small groups, explaining:

  1. Which animal does this affect?
  2. What is the trait being modified, and what “problem” does this solve? (e.g. engineering cattle to grow shorter hair so that they can withstand hotter climates)
  3. Is the intervention explicitly designed to improve animal welfare? Is it welfare-positive?
    1. If yes, explain the rationale. (e.g. “Yes. Enhanced disease resistance would reduce suffering from disease symptoms and antibiotic side effects.”)
    2. If no, anticipate potential harms that might arise.
  4. What are the non-welfare benefits, if any? What human interests might be motivating this intervention? (e.g. faster growth, breed standards, aesthetics, human convenience)
  5. If your chosen intervention is designed to improve animal welfare, what might be some alternative ways to address the same welfare issue? (e.g. non-genetic welfare improvements, or genetic approaches not using editing, such as selective breeding)
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Remember: Not all genetic interventions are welfare-positive. You can choose to present an intervention that does not necessarily decrease animal suffering.

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Not sure where to start? Check out the above section 🧬Week 5: The Genetic Welfare Frontier - Genetic modification in animals. You can also check the readings for links or citations. Focus on what interests you the most!

Stress-testing the argument for genetic modification for welfare

[150 words] Review Shriver’s ‘Potential Argument’ from 🧬Week 5: The Genetic Welfare Frontier - Knocking Out Pain in Livestock: Can Technology Succeed Where Morality has Stalled? (available open access here) (also copied below). Then, do two of the following:

  1. Choose one premise which you strongly agree or disagree with and explain why.
  2. Identify a consideration which the author may have overlooked and justify its importance.
  3. Identify the premise which you think is most controversial or uncertain and explain why.
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(View excerpt)

The following text is excerpted from the reading.

§ A Potential Argument I am now in a position to formulate an argument for the genetic engineering of animals reared in intensive factory farming environments:

  1. We should prevent unnecessary suffering when possible.
  2. Intensive factory farming is responsible for a considerable amount of unnecessary suffering.
  3. Replacing the current animals used in factory farming with genetically engineered animals who lack the affective dimension of pain would decrease the amount of suffering caused by factory farms.
  4. Not enough people are willing to become vegetarian to completely eliminate the suffering caused by intensive factory farming.
  5. People would be willing to eat genetically engineered food if it meant they were no longer responsible for suffering and if it did not impose too much of a burden on their lives.
  6. Animals can be genetically engineered and used in food production in a way that does not impose much of a burden on people’s lives.
  7. (7) Given (2), (3), (4), (5), and (6), replacing current livestock with genetically engineered animals who lack the affective dimension of pain would prevent unnecessary suffering.

Conclusion: From (1), and (7), we ought to replace current livestock with genetically engineered animals who lack the affective dimension of pain.

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